Peptide Mapping

Peptide Mapping

Biopharmaceutical Characterization — Sequence Characterization

Product Overview

Peptide Mapping protein testing, adoptProteases protein, use LC-MS/MStesting, protein protein amino acid sequence, proteindrug (CQA) throughPeptide Mapping method. throughPeptide Mapping proteinN/C, proteinamino acid sequence coverage, site,. Trypsin Peptide Mapping Proteases, Proteases Peptide Mapping 100% coverage, use Trypsin Lys-C, Glu-C, Chymotrypsin Proteases method 100% coverage.

Testing Purpose

technologymethod: Peptide Mapping

Test Category:

amino acid sequence

Testing Purpose:

drug amino acid sequence activity, clinical, Proteases (Lys-C, Asp-N Glu-C), technology amino acid sequence.

Test Category:

N, C

Testing Purpose:

N drugN method., Edman N. N/C combined with,. drug cellin vivo D, C., C, N/C,., throughN/C drug quality control.

Test Category:

Testing Purpose:

protein,. throughcombined with Peptide Mapping, 100%, amino acid sequence.

Test Category:

Testing Purpose:

Peptide Mapping,,, Glycosylation, N, C. (Met) (Trp),. drug, CDR (Asn), Asn (Gly) (NG),, CDR, combined with,.

Test Category:

N/O-Glycosylation(intact glycopeptide)

Testing Purpose:

Glycosylation drug. N "Asn X Ser/Thr"(X Pro) Asnsite; O, protein Ser Thr. Glycosylation activity,, CDC, ADCC ADCP; Glycosylation, α1,3 NGNA,, drug.

Test Category:

Disulfide Bond Analysis

Testing Purpose:

Disulfide Bond Analysis drug,. through drug,, drug quality control. Disulfide Bond Analysis,,.

Analysis Workflow


Analysis Workflow

Peptide MappingAnalysis Workflow

Main Deliverables

LC-MS_MSPeptide Mapping @2x.jpg

LC-MS/MSPeptide Mapping

Peptide Mapping amino acid sequence @2x.jpg

Peptide Mapping amino acid sequence  N @2x.jpg

N

ProteinResidue #Modification sitesCategorySequence%Abundance
HC55N55+DeamidationDeamidationIYPTNGYTR44.38
HC318N318+DeamidationDeamidationVVSVLTVLHQDWLNGK26.68
LC30N30+DeamidationDeamidationASQDVNTAVAWYQQKPGK12.56
HC387N387+DeamidationDeamidationGFYPSDIAVEWESNGQPENNYK7.42
HC392N392+DeamidationDeamidationGFYPSDIAVEWESNGQPENNYK5.81
HC217K217+Gln->Pyro-GluGln->Pyro-GluKVEPK5.86
HC374G374+Gln->Pyro-GluGln->Pyro-GluGFYPSDIAVEWESNGQPENNYK1.46
LC103K103+GlycationGlycationSGTDFTLTISSLQPEDFATYYCQQHY
TTPPTFGQGTKVEIK
1.1
LC149K149+GlycationGlycationVQWKVDNALQSGNSQESVTEQDSK0.85
HC329K329+GlycationGlycationVSNKALPAPIEK0.66
HC255M255+OxidationOxidationDTLMISR3.67
HC107M107+OxidationOxidationWGGDGFYAMDYWGQGTLVTVSSASTK1.88
HC431M431+OxidationOxidationWQQGNVFSCSVMHEALHNHYTQK1.35
HC83M83+OxidationOxidationNTAYLQMNSLR0.72
LC4M4+OxidationOxidationDIQMTQSPSSLSASVGDR0.63
HC39Q39+Gln->Pyro-GluGln->Pyro-GluQAPGK3.26
HC1E1-18.0106Gln->Pyro-GluEVQLVESGGGLVQPGGSLR3.69
HC249K249+GlycationGlycationTHTCPPCPAPELLGGPSVFLFPPKPK0.64
HC300N300+A2G0FN-GlycanEEQYNSTYR38.42
HC300N300+A2G1FN-GlycanEEQYNSTYR36.11
HC300N300+A1G0FN-GlycanEEQYNSTYR9.7
HC300N300+A2G2FN-GlycanEEQYNSTYR6.97
HC300N300+A2G0N-GlycanEEQYNSTYR3.37
HC300N300+A1G1FN-GlycanEEQYNSTYR3.24
HC300N300+A2G1N-GlycanEEQYNSTYR1.85

Peptide Mapping

Shenzhen Wininnovate Bio Co., Ltd.

Innovative mass spectrometry and AI technologies provide protein and metabolite mass spectrometry multi-omics solutions for life science research, empowering the growth of the biotechnology, pharmaceutical, and healthcare industries.

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Free trial
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