Product Overview
Disulfide bonds are a common post-translational modification of proteins, crucial for ensuring proper protein folding and maintaining higher-order protein structures. Abnormal disulfide bond linkages can affect protein structure and function; therefore, in biotherapeutic development, it is necessary to confirm the disulfide bond linkages and other potential variants of the product. Disulfide bond analysis requires enzymatic digestion of the protein under non-reducing conditions, followed by high-resolution mass spectrometry characterization of disulfide-bonded peptides to confirm the linkage pattern. Wininnovate Bio has established comprehensive methods for disulfide bond analysis, meeting customers' needs for disulfide bond conformation analysis and mismatched disulfide bond analysis.
Main disulfide bond linkage modes of different types of IgG
Analysis Process
Instrumental Platform
- Fusion Lumos
- Q-Exactive LC-MS
Key Deliverables
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Antibody (Trypsin/Lys-C) non-reductase cleavage peptide diagram
Antibody disulfide bond linkage
Protein disulfide bond MS/MS secondary mass spectra
Shenzhen Wininnovate Bio Co., Ltd.
Innovative mass spectrometry and AI technologies provide protein and metabolite mass spectrometry multi-omics solutions for life science research, empowering the growth of the biotechnology, pharmaceutical, and healthcare industries.
